Treatment Guidance

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1) Second Edition of Management of Multidrug-Resistant Tuberculosis in Children: A Field Guide. Boston, USA: The Sentinel Project for Pediatric Drug Resistant Tuberculosis; July 2014. Available here.

2) Seddon JA, Furin JJ, Gale M, Del Castillo Barrientos H, Hurtado RM, Amanullah F, Ford N, Starke JR, Schaaf HS. Caring for children with drug-resistant tuberculosis: Practice-based recommendations. Am J Respir Crit Care Med 2012; 186(10):953-964. Available at the American Journal of Respiratory and Critical Care Medicine.

3) This dosing chart provides recommendations for the acceptable doses of second-line TB drugs for children.  This chart, available here, was developed by a team of experts in November 2013 based on published data as well as new PK data on the fluoroquinolones and aminoglycosides.  The doses are based on weight bands and use tablet sizes currently available in most TB programs.  Because children being treated for DR-TB often gain weight quickly, it is recommended that dose adjustments be considered on a regular basis (i.e. monthly).  For important disclaimers on the use of this dosing chart, please refer to the disclaimer section available in the Sentinel Project’s “Management of Drug-Resistant Tuberculosis in Children: A Field Guide.”

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  1. […] Tuberculosis: A Field Guide is now available and available for download on the Treatment Guidance […]

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